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This paper presents a theoretical nonstationary stochastic analysis scheme using pseudo-excitation method (PEM) for seismic analysis of long-span structures under tridirectional spatially varying ground motions, based on which the local site effects on structural seismic response are studied for a high-pier railway bridge. An absolute-response-oriented scheme of PEM in nonstationary stochastic analysis of structure under tridirectional spatial seismic motions, in conjunction with the derived mathematical scheme in modeling tridirectional nonstationary spatially correlated ground motions, is proposed to resolve the drawbacks of conventional indirect approach. To apply the proposed theoretical approach readily in stochastic seismic analysis of complex and significant structures, this scheme is implemented and verified in a general finite element platform, and is then applied to a high-pier railway bridge under …