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Automotive is considered one of the driving use cases for the 5th Generation (5G) systems, which currently formulates numerous scenarios and Key Performance Indicators (KPIs), via advanced Vehicle-to-everything (V2X) services and applications. Minimum end-to-end delay, as well as advanced contextual awareness requirements, pose novel architectural and functional challenges. This paper exploits two key enablers, namely Multiple Access/Mobile Edge Computing (MEC) and Network Function Virtualization (NFV), and acts in a two-fold manner: Firstly, it proposes a hybrid architecture for 5G systems, which exploits the afore-mentioned technologies, and performs computing resources’ selection among MEC and/or centralized, cloud-based resources (as VNFs), towards efficient service orchestration. The second contribution of this paper is a novel V2X service and algorithm, namely VRU-safe, that operates on …