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Cyber-physical systems (CPS) are recognized for their intelligence as they seamlessly interact with humans, enhancing the physical world through computation, communication, and control. Over the last few years, the evolution of CPS, including IoT components, has significantly impacted many facets of people’s lifestyles. It has been immersed in a wide range of services and applications in various areas, including manufacturing, healthcare, and energy. However, the interrelationship between the cyber and physical worlds gives rise to a multitude of research problems and challenges. In the healthcare field, for instance, CPS introduces complexities related to interoperability, privacy, data security, and real-time data processing with critical implications for the reliability and safety of medical processes. To address these challenges and harness the full potential of CPS in healthcare, this paper, through a …