作者
Shengnan Li, Dexing Lin, Yunwei Zhang, Min Deng, Yongxing Chen, Bin Lv, Boshu Li, Yuan Lei, Yanpeng Wang, Long Zhao, Yueting Liang, Jinxing Liu, Kunling Chen, Zhiyong Liu, Jun Xiao, Jin-Long Qiu, Caixia Gao
发表日期
2022/2/17
期刊
Nature
卷号
602
期号
7897
页码范围
455-460
出版商
Nature Publishing Group UK
简介
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring disease resistance,. However, S genes are implicated in many essential biological functions and deletion of these genes typically results in undesired pleiotropic effects. Loss-of-function mutations in one such S gene, Mildew resistance locus O (MLO), confers durable and broad-spectrum resistance to powdery mildew in various plant species,. However, mlo-associated resistance is also accompanied by growth penalties and yield losses,, thereby limiting its widespread use in agriculture. Here we describe Tamlo-R32, a mutant with a 304-kilobase pair targeted deletion in the MLO-B1 locus of wheat that retains crop growth and yields while conferring robust powdery mildew resistance. We show that this deletion results in an altered local chromatin landscape, leading to the ectopic activation of Tonoplast monosaccharide …
学术搜索中的文章
S Li, D Lin, Y Zhang, M Deng, Y Chen, B Lv, B Li, Y Lei… - Nature, 2022