作者
Peter St George-Hyslop, Jonathan Haines, EI Rogaev, M Mortilla, G Vaula, Margaret Pericak-Vance, Jean-Francois Foncin, MP Montesi, AC Bruni, Sandro Sorbi, Innocenzo Rainero, Lorenzo Pinessi, D Pollen, Rj Polinsky, L Nee, Jl Kennedy, F Macciardi, E Rogaeva, Y Liang, N Alexandrova, W Lukiw, K Schlumpf, R Tanzi, T Tsuda, L Farrer, JM Cantu, R_ Duara, L Amaducci, L Bergamini, J Gusella, A Roses, D Crapper McLachlan
发表日期
1992/12/1
期刊
Nature genetics
卷号
2
期号
4
页码范围
330-334
出版商
Nature Publishing Group US
简介
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score ẑ = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.
引用总数
学术搜索中的文章
P St George-Hyslop, J Haines, EI Rogaev, M Mortilla… - Nature genetics, 1992