作者
Robert C Green, L Adrienne Cupples, Alex Kurz, Sanford Auerbach, Rodney Go, Dessa Sadovnick, Ranjan Duara, Walter A Kukull, Helena Chui, Timi Edeki, Patrick A Griffith, Robert P Friedland, David Bachman, Lindsay Farrer
发表日期
2003/5/1
期刊
Archives of neurology
卷号
60
期号
5
页码范围
753-759
出版商
American Medical Association
简介
Background
Depression symptoms may be associated with the development of Alzheimer disease (AD).
Objectives
To evaluate the association between depression symptoms and risk of AD, and to explore the temporal aspects of this association.
Setting
Academic institutions with specialized memory clinics.
Design
Cross-sectional, family-based, case-control study with standardized self- and proxy questionnaires to collect information on depression symptoms and other risk factors.
Participants
A total of 1953 subjects with AD and 2093 of their unaffected relatives enrolled in the Multi-institutional Research in Alzheimer's Genetic Epidemiology Study.
Main Outcome Measures
Odds ratios (ORs) of AD were estimated with and without depression symptoms, adjusted for age, sex, education, history of head trauma, and apolipoprotein E status.
Results
There was a significant association between depression symptoms and AD …
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RC Green, LA Cupples, A Kurz, S Auerbach, R Go… - Archives of neurology, 2003