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In this paper, we describe the validation of GNPy. GNPy is an open source application that approaches the optical layer according to a disaggregated paradigm, and its core engine is a quality-of-transmission estimator for coherent wavelength division multiplexed optical networks. This software is versatile. It can be used to prepare a request for proposal/request for quotation, as an engine of a what-if analysis on the physical layer, to optimize the network configuration to maximize the channel capacity, and to investigate the capacity and performance of a deployed network. We validate GNPy by feeding it with data from the network controller and comparing the results to experimental measurements on mixed-fiber, Raman-amplified, multivendor scenarios over the full C-band. We then test transmission distances from 400 up to 4000 km, polarization-multiplexed (PM) quadrature phase shift keying, the PM-8 …