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To effectively operate multivendor disaggregated networks, the performance of the physical layer needs to be assessed by a quality-of transmission estimator (QoT-E) delivering quick results with a given reliability range. Current state-of-the-art wavelength-division-multiplexing channels are based on multilevel modulation formats relying on DSP-operated coherent receivers, propagating on uncompensated and amplified optical links. In this transmission scenario, beside amplified spontaneous emission noise accumulation, nonlinear propagation impairments are well summarized by the accumulation of a Gaussian-distributed disturbance: the nonlinear interference (NLI). When exploiting a transmission bandwidth exceeding the C-band, the interaction of NLI generation with the stimulated Raman scattering (SRS) must be properly considered. We present the derivation of the generalized Gaussian noise (GGN …