作者
Stephen N Crooke, Jukuan Zheng, Mitra S Ganewatta, Sophia M Guldberg, Theresa M Reineke, MG Finn
发表日期
2018/12/10
期刊
ACS Applied Bio Materials
卷号
2
期号
1
页码范围
93-103
出版商
American Chemical Society
简介
The covalent attachment of polymers to the surface of proteins and nanoparticles has been widely employed in the development of biomedical platforms capable of delaying or diminishing immune surveillance. The most widely employed polymer for these applications has been poly(ethylene glycol) (PEG), yet recent evidence has suggested that other polymer architectures and compositions provide significantly better in vitro and in vivo properties of protein–polymer hybrid materials. Moreover, few direct comparisons of PEG to these polymers have been reported. Here we describe the assembly and characterization of a series of polymer conjugates of a representative immunogenic viruslike particle (VLP) using (poly(oligo(ethylene glycol) methacrylate), poly(methacrylamido glucopyranose), and PEG, and an investigation of their ability to shield the protein from antibody recognition as a function of polymer loading …
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SN Crooke, J Zheng, MS Ganewatta, SM Guldberg… - ACS Applied Bio Materials, 2018