作者
M Thomas Morgan, S Sumalekshmy, Mysha Sarwar, Hillary Beck, Stephen Crooke, Christoph J Fahrni
发表日期
2014/12/11
期刊
The Journal of Physical Chemistry B
卷号
118
期号
49
页码范围
14196-14202
出版商
American Chemical Society
简介
Ternary complex formation with solvent molecules and other adventitious ligands may compromise the performance of metal-ion-selective fluorescent probes. As Ca(II) can accommodate more than 6 donors in the first coordination sphere, commonly used crown ether ligands are prone to ternary complex formation with this cation. The steric strain imposed by auxiliary ligands, however, may result in an ensemble of rapidly equilibrating coordination species with varying degrees of interaction between the cation and the specific donor atoms mediating the fluorescence response, thus diminishing the change in fluorescence properties upon Ca(II) binding. To explore the influence of ligand architecture on these equilibria, we tethered two structurally distinct aza-15-crown-5 ligands to pyrazoline fluorophores as reporters. Due to ultrafast photoinduced electron-transfer (PET) quenching of the fluorophore by the ligand …
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Probing ternary complex equilibria of crown ether ligands by time-resolved fluorescence spectroscopy
MT Morgan, S Sumalekshmy, M Sarwar, H Beck… - The Journal of Physical Chemistry B, 2014