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Robot-assisted therapy is regarded as an effective and reliable method for the delivery of highly repetitive training that is needed to trigger neuroplasticity following a stroke. This study focuses on the pre-defined research gaps by combining adaptive assist-as-needed control and immersive virtual environment (VE) into a rehabilitation system, with special attention on the rehabilitation of fine hand motion skills. The virtual reality-based integrated rehabilitation system using Oculus Rift DK2 head mounted display, featuring rehabilitation gaming system with rendering immersive VE is proposed to strengthen activities of daily living and task-oriented kinematic features such as force, range of motion (ROM) and finger coordination. The effectiveness of the system is examined by conducting clinical trials on a group of 8 subacute stroke patients for a period of six weeks with 18 training sessions. The results are verified …