作者
Leonardo Rojas‐Puentes, Andrés F Cardona, Hernán Carranza, Carlos Vargas, Luis F Jaramillo, Delma Zea, Lucely Cetina, Beatriz Wills, Erika Ruiz‐Garcia, Oscar Arrieta
发表日期
2016/8
期刊
Cancer medicine
卷号
5
期号
8
页码范围
1989-1999
简介
We evaluated the association between epithelial–mesenchymal transition (EMT)‐derived markers and expression of proteins associated with cell proliferation and tumor growth, as well as their prognostic roles, in 61 patients (mean age 52 ± 10 years) with locally advanced cervical cancer, all of whom were treated with chemoradiation and intracavitary brachytherapy. We used immunohistochemical analysis to assess the expression of proteins targeted in our investigation. Various statistical analyses were then conducted to assess protein marker associations with survival outcomes. Forty‐six percent of the patients were positive for human papilloma virus. Median progression‐free survival (PFS) was 6.6 months (95% confidence interval [CI]: 4.0–9.1, whereas overall survival (OS) was 30.0 months (95% CI: 11–48). Multivariate analysis demonstrated that vascular endothelial growth factor (VEGF) (P = 0.002 …
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L Rojas‐Puentes, AF Cardona, H Carranza, C Vargas… - Cancer medicine, 2016