作者
Christian Montag, Sebastian Markett, Ulrike Basten, Christine Stelzel, Christian Fiebach, Turhan Canli, Martin Reuter
发表日期
2010/8
期刊
Neuropsychopharmacology
卷号
35
期号
9
页码范围
1860-1867
出版商
Nature Publishing Group
简介
Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N= 768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D 2 receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies …
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C Montag, S Markett, U Basten, C Stelzel, C Fiebach… - Neuropsychopharmacology, 2010