作者
Jordana B Cohen, Sarah J Schrauben, Lei Zhao, Michael D Basso, Mary Ellen Cvijic, Zhuyin Li, Melissa Yarde, Zhaoqing Wang, Priyanka T Bhattacharya, Diana A Chirinos, Stuart Prenner, Payman Zamani, Dietmar A Seiffert, Bruce D Car, David A Gordon, Kenneth Margulies, Thomas Cappola, Julio A Chirinos
发表日期
2020/3/1
期刊
Heart failure
卷号
8
期号
3
页码范围
172-184
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess if clinical phenogroups differ in comprehensive biomarker profiles, cardiac and arterial structure/function, and responses to spironolactone therapy.
Background
Previous studies identified distinct subgroups (phenogroups) of patients with heart failure with preserved ejection fraction (HFpEF).
Methods
Among TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial) participants, we performed latent-class analysis to identify HFpEF phenogroups based on standard clinical features and assessed differences in multiple biomarkers measured from frozen plasma; cardiac and arterial structure/function measured with echocardiography and arterial tonometry; prognosis; and response to spironolactone.
Results
Three HFpEF phenogroups were identified. Phenogroup 1 (n = 1,214) exhibited younger age, higher prevalence of smoking …
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JB Cohen, SJ Schrauben, L Zhao, MD Basso, ME Cvijic… - Heart failure, 2020