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Building optimization involving multiple objectives is generally an extremely time-consuming process. The GAINN approach presented in this study first uses a simulation-based Artificial Neural Network (ANN) to characterize building behaviour, and then combines this ANN with a multiobjective Genetic Algorithm (NSGA-II) for optimization. The methodology has been used in the current study for the optimization of thermal comfort and energy consumption in a residential house. Results of ANN training and validation are first discussed. Two optimizations were then conducted taking variables from HVAC system settings, thermostat programming, and passive solar design. By integrating ANN into optimization the total simulation time was considerably reduced compared to classical optimization methodology. Results of the optimizations showed significant reduction in terms of energy consumption as well as …