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Purpose:

Tear hyperosmolarity is diagnostic of dry eye disease (DED), yet difficulty in measurement has limited its utility; development of new instruments could facilitate its clinical application. This study compares the new OcuSense TearLab osmometer (OcuSense, Inc, San Diego, CA), based on electrical impedance “lab-on-a-chip” nanoliter technology, with the freezing point depression Clifton Osmometer (Clifton Technical Physics, Hartford, NY).

Methods:

Thirty-six subjects were recruited: 15 DED (9 women, 6 men age: 41±16 years) and 21 controls (12 women, 9 men age: 35±12 years); criteria for DED were noninvasive tear breakup time< 10 seconds, Schirmer I test< 5 mm, and positive symptoms. Samples were collected from the inferior tear meniscus for testing with both osmometers.

Results:

Osmolarity values measured with OcuSense TearLab were 308±6 and 321±16 mOsm/L for controls and dry eye …