作者
Alessio Mazzoni, Laura Maggi, Manuela Capone, Anna Vanni, Michele Spinicci, Lorenzo Salvati, Seble Tekle Kiros, Roberto Semeraro, Luca Pengue, Maria Grazia Colao, Alberto Magi, Gian Maria Rossolini, Francesco Liotta, Lorenzo Cosmi, Alessandro Bartoloni, Francesco Annunziato
发表日期
2021
期刊
Clinical & Translational Immunology
卷号
10
期号
5
页码范围
e1281
简介
Objective
Although the adaptive immune response to SARS‐CoV‐2 has been characterised in the acute and early convalescent phase of the disease, few studies explore whether natural infection elicits long‐lasting immunological memory in recovered individuals. In this work, we aimed to assess the maintenance of immunological memory to SARS‐CoV‐2.
Methods
We evaluated the long‐term virus‐specific cellular and humoral immune response in the members of an Italian Serie A football team, who experienced a cluster of COVID‐19 in March 2020, which was strictly evaluated in the following months.
Results
Our results highlight a heterogeneous magnitude of immunological memory at 5 months after infection. Indeed, 20% of the subjects displayed a weak cellular and humoral memory to SARS‐CoV‐2, suggesting that they may be at higher risk of reinfection. In addition, a history of symptomatic COVID‐19 …
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A Mazzoni, L Maggi, M Capone, A Vanni, M Spinicci… - Clinical & Translational Immunology, 2021