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In real-life applications of wireless sensor networks (WSNs), optimization of the network operation is required to extend its lifetime. A framework is proposed that enables practical development of centralized cluster-based protocols supported by optimization methods for the WSNs. Based on this framework, a protocol using harmony search algorithm (HSA), a music-based meta-heuristic optimization method, is designed and implemented in real time for the WSNs. It is expected to minimize the intra-cluster distances between the cluster members and their cluster heads (CHs) and optimize the energy distribution of the WSNs. The study of HSA cluster-based protocol is carried out in a real case where the WSNs equipped with the proposed protocol are deployed in an indoor environment to monitor the ambient temperature for fire detection. A comparison is made with the well-known cluster-based protocols developed …