作者
DR Padhya, GJ Prutsky, ME Nemergut, GS Schears, RP Flick, W Farah, Zhen Wang, LJ Prokop, Mohammad H Murad, M Alsawas
发表日期
2019/7/1
来源
Thrombosis research
卷号
179
页码范围
132-139
出版商
Pergamon
简介
Objective
Specific protocols for anticoagulation for children on ECMO vary across institutions, with most using a continuous infusion of unfractionated heparin. The goal of this study is to aid clinician's decision on the best measure of heparin anticoagulation test; which would be the one that correlates well with heparin activity and helps in predicting hemorrhagic and thrombotic complications.
Data sources
A comprehensive search of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus was conducted from each database's inception to 07/13/2018.
Study selection
Studies evaluating children (<18 years) treated with ECMO and evaluating ACT, aPTT, TEG and Anti-Xa in any language were included.
Data extraction
Two reviewers selected and appraised studies independently, and abstracted data.
Results
We included 19 studies (759 patients, mean age 19.8 months). Meta-analysis showed …
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DR Padhya, GJ Prutsky, ME Nemergut, GS Schears… - Thrombosis research, 2019