作者
Tarig Elraiyah, Apostolos Tsapas, Gabriela Prutsky, Juan Pablo Domecq, Rim Hasan, Belal Firwana, Mohammed Nabhan, Larry Prokop, Anil Hingorani, Paul L Claus, Lawrence W Steinkraus, Mohammad Hassan Murad
发表日期
2016/2/1
来源
Journal of vascular surgery
卷号
63
期号
2
页码范围
46S-58S. e2
出版商
Mosby
简介
Background
Multiple adjunctive therapies have been proposed to accelerate wound healing in patients with diabetes and foot ulcers. The aim of this systematic review is to summarize the best available evidence supporting the use of hyperbaric oxygen therapy (HBOT), arterial pump devices, and pharmacologic agents (pentoxifylline, cilostazol, and iloprost) in this setting.
Methods
We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus through October 2011. Pairs of independent reviewers selected studies and extracted data. Predefined outcomes of interest were complete wound healing and amputation.
Results
We identified 18 interventional studies; of which 9 were randomized, enrolling 1526 patients. The risk of bias in the included studies was moderate. In multiple randomized trials, the addition of HBOT to conventional therapy (wound care and offloading …
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T Elraiyah, A Tsapas, G Prutsky, JP Domecq, R Hasan… - Journal of vascular surgery, 2016