作者
Lila Bouadma, Armand Mekontso-Dessap, Charles Burdet, Hamid Merdji, Julien Poissy, Claire Dupuis, Christophe Guitton, Carole Schwebel, Yves Cohen, Cedric Bruel, Mehdi Marzouk, Guillaume Geri, Charles Cerf, Bruno Mégarbane, Pierre Garçon, Eric Kipnis, Benoit Visseaux, Naima Beldjoudi, Sylvie Chevret, Jean-François Timsit, Céline Alloux, Fadila Amerali, Béatrice Andriss, Kamyl Baghli, Hélène Brocvielle, Florence Capelle, Ines Chibane, Sarra Dalibey, Nadia Ettalhaoui, Sabrine Lamri, Yohan Maurer, Jean-Marc Mintsa, Alice Oubahim, Marie-Capucine Tellier, Imane Zemihi, Moustafa Abdel-Nabey, Billal Azzouguen, Ghenima Belkessa, Etienne De Montmollin, Veronique Deiler, Aline Fallet, Guillaume Franchineau, Tiphaine Girard, Alexandra Grinea, Pierre Jaquet, Laura Kramer, Fariza Lamara, Lucie Lefevre, Juliette Patrier, Simona Presente, Faiza Sayagh, Fabrice Sinnah, Romain Sonneville, Paul-Henri Wicky, Sylia Zmihi, Nathalie Barget, Rawan Belmokhtar, Sabrina Brahmi, Naoual Djabra, Nathan Ebstein, Souha Fliss, Amina Gourbdji, William Juguet, Fadhila Messani, Thomas Rambaud, Vanessa Rathouin, Marthe Rigal, Julien Schmidt, Marie Soulie, Yacine Tandjaoui-Lombiotte, Anaïs Winchenne, Marianne Ziol, Romain Arrestier, François Bagate, Morgan Benais, Ines Bendib, LE Lan, Brice Benelli, Enora Berti, Astrid Bertier, Guillaume Carteaux, Muriel Carvalho, Pedro Cavaleiro, Nicolas Deprost, Otto Hartman, Anne-Fleur Haudebourg, Delphine Le Febvre De Nailly, Julien Lopinto, Sabrina Mahiou, Paul Masi, Gaël Michaud, Luiza Nait-Chabane, Fariza Ouali, François Perier, Keyvan Razazi, Thiziri Sadaoui, Alaki Thiemele, Samuel Tuffet, Flavien Autron, Pauline Boddaert, Sylvie Brice, Morgan Caplan, Amélie Cerf, Nicolas Cousin, Marie Cuvelliez, Claire Delcourte, Arthur Durand, Raphaël Favory, Ahmed El Kalioubie, Myrtille Gaudel, Alexandre Gaudet, Julien Goutay, Marion Houard, Emmanuelle Jaillette, Mercé Jourdain, Geoffrey Ledoux, Laure Mariller, Guillaume Millot, Anne-Sophie Moreau, Christopher Niles, Saad Nseir, Thierry Onimus, Sébastien Preau, Aurélie Roucou, Anahita Rouze, Ouriel Saura, Arthur Simonnet, Romain Tortuyaux, Hayat Allam, Jessy Cattelan, Raphaël Clere-Jehl, Julie Helms, Kévin Hilt, Anne Hutt-Clauss, Christine Kummerlen, Ferhat Meziani, Alexandra Monnier, Hassène Rahmani, Antoine Studer, Leonie Thiebaut, Aurélie Han Hew Wai, David Cortier, Jérôme Devaquet, Dimitri Fremont, Richard Galliot, Fabienne Juster, Mathilde Le Marchand, Lucie Le Meur, Mathilde Neuville, Emmanuel Roux
发表日期
2022/9/1
期刊
JAMA internal medicine
卷号
182
期号
9
页码范围
906-916
出版商
American Medical Association
简介
Importance
The benefit of high-dose dexamethasone and oxygenation strategies vs standard of care for patients with severe acute hypoxemic respiratory failure (AHRF) caused by COVID-19 pneumonia is debated.
Objectives
To assess the benefit of high-dose dexamethasone compared with standard of care dexamethasone, and to assess the benefit of high-flow nasal oxygen (HFNo2) or continuous positive airway pressure (CPAP) compared with oxygen support standard of care (o2SC).
Design, Setting, and Participants
This multicenter, placebo-controlled randomized clinical trial was conducted in 19 intensive care units (ICUs) in France from April 2020 to January 2021. Eligible patients were consecutive ICU-admitted adults with COVID-19 AHRF. Randomization used a 2 × 3 factorial design for dexamethasone and oxygenation strategies; patients not eligible for at least 1 oxygenation strategy and/or already …
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L Bouadma, A Mekontso-Dessap, C Burdet, H Merdji… - JAMA internal medicine, 2022