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Instruction in Systems Thinking and Design at the undergraduate and graduate level has strongly emphasized that systems performance is dependent upon efficiency. However, in most cases, efficiency as the sole target provides results that do not represent the state of a system in its entirety. In response to these issues, members of the Center for Advanced Systems Research (CASRE), at The University of Tennessee, Knoxville have developed methods to teach systems thinking through the concept of reliability. Changing the paradigm from efficiency to reliability in both the undergraduate and graduate-level courses on Reliability Engineering has demonstrably improved the students’ understanding of systems analysis. Instead of the efficiency-based system analysis, it is possible to dive deeper and evaluate systems’ behavior with respect to their intended function over specified periods of time. This approach enables the analysis of each system component, breakdown of the component’s failure modes, elaboration of the system as a collection of networks, and the role of people within systems. The result is the establishment of reliability-based performance metrics, to identify and mitigate variations and disruptions within systems. The next phase comprises a hands-on experience, where students perform a reliability analysis of chosen systems at their companies. These analyses support the development of reliability-based solutions for systems and sustainability plan to enhance the employees’ quality of life. The combination of a strong curriculum in systems thinking and engineering, along with people-centric reliability, has yielded several …