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Diabetes mellitus is one of the most widely distributed metabolic disorders and occurs in almost all populations of the world at a variable prevalence. Diabetic patients commonly have a decreased activity of granulocytes. The aim of this study is to evaluate the activity of granulocytes and assess the effectiveness of zinc sulphate on the activity of granulocytes in diabetic patients. The study includes one-hundred and forty subjects, eighty had diabetes mellitus (forty males and forty females), and sixty healthy subjects (forty-nine males and eleven females). The activity of granulocytes was studied by the chemiluminescence technique for diabetic patients and healthy subjects. There was highly significant difference (P< 0.001) in the activity of granulocytes between the healthy subjects and diabetic patients, also there was a significant difference (P< 0.01) in the activity of granulocytes between males and females diabetic patients and males and females healthy subjects. We studied the influence of zinc sulphate on phagocytic activity of granulocytes of diabetic patients and healthy subjects, the study shows that the mean and SD for granulocytes activity and low concentrations of zinc sulphate (0.1, 1, 5 and 10) µg/ml for diabetic patients and healthy subjects, there were no significant differences in the activity of granulocytes between the control (zinc concentration= 0) and the test sample (with zinc sulphate) at different low concentrations of zinc sulphate. The study included effect of different concentrations of zinc (0.68 mg/ml, 1.36 mg/ml, 2.05 mg/ml, 2.73 mg/ml and 3.41 mg/ml), there were significant differences (P< 0.01) in the phagocytic activity of …