作者
Reem T Atawia, Jessica L Faulkner, Vinay Mehta, Andrew Austin, Coleton R Jordan, Simone Kennard, Eric J Belin De Chantemele
发表日期
2022/10/1
期刊
Vascular pharmacology
卷号
146
页码范围
107093
出版商
Elsevier
简介
Leptin plays a crucial role in blood pressure (BP) regulation, notably in the context of obesity through central sympatho-mediated pressor effects. Leptin also relaxes arteries via endothelial (EC) leptin receptor (LepREC)-mediated increases in nitric oxide (NO) bioavailability. Herein, we investigated whether leptin-mediated increases in NO bioavailability represent a buffering mechanism against leptin-induced sympatho-activation. We tested the direct contribution of LepREC to BP regulation in physiological conditions and in response to chronic leptin infusion using mice deficient in LepREC. LepREC deficiency did not alter baseline metabolic profile nor leptin-induced reduction in adiposity and increases in energy expenditure. LepREC−/− mice demonstrated no increase in baseline BP and heart rate (HR) (MAP: LepREC+/+:94.7 ± 1.6, LepREC−/−:95.1 ± 1.8 mmHg; HR:LepREC+/+:492.4 ± 11.7, LepREC−/−:509.5 …
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