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Centella asiatica (CA) (also known as Mandukaparni) an effective neuroprotective and there for also called brain tonic. The plant has been used in Ayurveda and other Asian traditional medicine system as a memory enhancing drug. It is distributed throughout tropical and subtropical countries from 200 to 2100 m a.s.l. and is native to Asia, Africa, America. The plant is rich in carotenoids Vitamins B & C content. The protective effect on the central nervous system is generally associated to its bioactive compounds including asiatic acid, madecassic acid, asiaticoside, madecassoside, and brahmic acid. CA has been reported to have a comprehensive neuroprotection by different modes of action such as enzyme inhibition, prevention of amyloid plaque formation in Alzheimer’s disease, decreasing oxidative stress etc. This makes CA a desired herb for Alzheimer’s disease.