作者
Ruth O'Hara, Peter Marcus, Wesley K Thompson, John Flournoy, Ipsit Vahia, Xiaoyan Lin, Joachim Hallmayer, Colin Depp, Dilip V Jeste
发表日期
2012/5/1
期刊
The American Journal of Geriatric Psychiatry
卷号
20
期号
5
页码范围
452-456
出版商
Elsevier
简介
Objective
Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults.
Methods
In a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health.
Results
There was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging.
Conclusion
These findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status …
学术搜索中的文章
R O'Hara, P Marcus, WK Thompson, J Flournoy, I Vahia… - The American Journal of Geriatric Psychiatry, 2012