作者
Koji Kamagata, Yumiko Motoi, Masaaki Hori, Michimasa Suzuki, Atsushi Nakanishi, Keigo Shimoji, Shinsuke Kyougoku, Ryohei Kuwatsuru, Keisuke Sasai, Osamu Abe, Yoshikuni Mizuno, Shigeki Aoki, Nobutaka Hattori
发表日期
2011/4
期刊
Journal of Magnetic Resonance Imaging
卷号
33
期号
4
页码范围
803-807
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Purpose
To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD).
Materials and Methods
Thirty‐five PD patients, 11 PDD patients, and 35 normal controls were scanned by using a quantitative ASL method with a 3 Tesla MRI unit. Regional cerebral blood flow was compared in the posterior cortex using region‐of‐interest analysis.
Results
PD and PDD patients showed lower regional cerebral blood flow in the posterior cortex than normal controls (P = 0.002 and P = 0.001, respectively, analysis of variance with a Bonferroni post hoc test).
Conclusion
This is the first study to detect hypoperfusion in the posterior cortex in PD and PDD patients using ASL perfusion MRI. Because ASL perfusion MRI is completely noninvasive and can, therefore, safely be used for repeated assessments …
学术搜索中的文章
K Kamagata, Y Motoi, M Hori, M Suzuki, A Nakanishi… - Journal of Magnetic Resonance Imaging, 2011