作者
Mariko Yoshida, Masaaki Hori, Kazumasa Yokoyama, Issa Fukunaga, Michimasa Suzuki, Koji Kamagata, Keigo Shimoji, Atsushi Nakanishi, Nobutaka Hattori, Yoshitaka Masutani, Shigeki Aoki
发表日期
2013/1
期刊
Japanese journal of radiology
卷号
31
页码范围
50-55
出版商
Springer Japan
简介
Purpose
We evaluated diffusional changes in normal-appearing white matter (NAWM) regions remote from multiple sclerosis (MS) plaques by using diffusional kurtosis imaging (DKI) to investigate the non-Gaussian behavior of water diffusion.
Materials and methods
Participants were 11 MS patients and 6 age-matched healthy volunteers. DKI was performed on a 3-T MR imager. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and diffusional kurtosis (DK) maps were computed. Regions of interest (ROIs) were compared in 24 cerebral regions, including the frontal, parietal, and temporal lobe white matter (WM) in controls and NAWM in MS patients.
Results
The mean FA of all ROIs was 0.468 ± 0.014 (SD) (controls) or 0.431 ± 0.029 (MS group) (P = 0.016). Mean ADC was 0.785 ± 0.034 × 10−3 mm2/s …
学术搜索中的文章
M Yoshida, M Hori, K Yokoyama, I Fukunaga, M Suzuki… - Japanese journal of radiology, 2013