作者
Koji Kamagata, Taku Hatano, Ayami Okuzumi, Yumiko Motoi, Osamu Abe, Keigo Shimoji, Kouhei Kamiya, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Nobutaka Hattori, Shigeki Aoki
发表日期
2016/8
期刊
European radiology
卷号
26
页码范围
2567-2577
出版商
Springer Berlin Heidelberg
简介
Objectives
We used neurite orientation dispersion and density imaging (NODDI) to quantify changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease (PD).
Methods
Diffusion-weighted magnetic resonance images were acquired from 58 PD patients and 36 age- and sex-matched controls. The intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia were compared between groups. Multivariate logistic regression analysis determined which diffusion parameters were independent predictors of PD. Receiver operating characteristic (ROC) analysis compared the diagnostic accuracies of the evaluated indices. Pearson coefficient analysis correlated each diffusional parameter with disease severity.
Results
Vic in the …
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K Kamagata, T Hatano, A Okuzumi, Y Motoi, O Abe… - European radiology, 2016