作者
Karolina A Aberg, Youfang Liu, Jozsef Bukszár, Joseph L McClay, Amit N Khachane, Ole A Andreassen, Douglas Blackwood, Aiden Corvin, Srdjan Djurovic, Hugh Gurling, Roel Ophoff, Carlos N Pato, Michele T Pato, Brien Riley, Todd Webb, Kenneth Kendler, Mick O’Donovan, Nick Craddock, George Kirov, Mike Owen, Dan Rujescu, David St Clair, Thomas Werge, Christina M Hultman, Lynn E Delisi, Patrick Sullivan, Edwin J Van Den Oord
发表日期
2013/6/1
期刊
JAMA psychiatry
卷号
70
期号
6
页码范围
573-581
出版商
American Medical Association
简介
Importance
Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is critical to improve disease understanding and address the urgent need for new drug targets.
Objective
To identify SCZ susceptibility genes.
Design
We integrated results from a meta-analysis of 18 genome-wide association studies (GWAS) involving 1 085 772 single-nucleotide polymorphisms (SNPs) and 6 databases that showed significant informativeness for SCZ. The 9380 most promising SNPs were then specifically genotyped in an independent family-based replication study that, after quality control, consisted of 8107 SNPs.
Setting
Linkage meta-analysis, brain transcriptome meta-analysis, candidate gene database, OMIM, relevant mouse studies, and expression quantitative trait locus databases.
Patients
We included 11 185 cases and 10 768 control …
学术搜索中的文章
KA Aberg, Y Liu, J Bukszár, JL McClay, AN Khachane… - JAMA psychiatry, 2013