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Epidemiological studies have established a relationship between low levels of serum vitamin D and reduced lung function in healthy adults, and asthma onset and severity in children. However, no study has examined the relationship between vitamin D levels and exercise-induced bronchoconstriction in asthmatic children.

We evaluated the relationship between 25-hydroxyvitamin D concentrations and baseline forced vital capacity (FVC), forced expiratory volume in 1 s (FEV₁) and change in FEV₁ (ΔFEV₁) after a standardised exercise challenge in 45 children with intermittent asthma.

Only 11% of the children had desirable serum vitamin D levels (at least 30–40 ng·mL⁻¹). A positive correlation was found between serum 25-hydroxyvitamin D and both FVC (r = 0.34; p = 0.037) and FEV₁ (r = 0.32; p = 0.037). Subjects with a positive response to the exercise challenge (ΔFEV₁ ≥10%) presented lower serum levels of …