作者
Cristina Molina Hidalgo, Audrey M Collins, Mary E Crisafio, George Grove, Thomas W Kamarck, Chaeryon Kang, Regina L Leckie, Madison MacDonald, Stephen B Manuck, Anna L Marsland, Matthew F Muldoon, Javier Rasero, Mark R Scudder, Daniel Velazquez-Diaz, Timothy Verstynen, Lu Wan, Peter J Gianaros, Kirk I Erickson
发表日期
2023/11/1
期刊
BMJ open
卷号
13
期号
11
页码范围
e077905
出版商
British Medical Journal Publishing Group
简介
Introduction
Physical activity (PA) has beneficial effects on brain health and cardiovascular disease (CVD) risk. Yet, we know little about whether PA-induced changes to physiological mediators of CVD risk influence brain health and whether benefits to brain health may also explain PA-induced improvements to CVD risk. This study combines neurobiological and peripheral physiological methods in the context of a randomised clinical trial to better understand the links between exercise, brain health and CVD risk.
Methods and analysis
In this 12-month trial, 130 healthy individuals between the ages of 26 and 58 will be randomly assigned to either: (1) moderate-intensity aerobic PA for 150 min/week or (2) a health information control group. Cardiovascular, neuroimaging and PA measurements will occur for both groups before and after the intervention. Primary outcomes include changes in (1) brain structural areas (ie …
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CM Hidalgo, AM Collins, ME Crisafio, G Grove… - BMJ open, 2023