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We [1, 2] and others [3- 5] have been interested in designing and making new molecules that have biological activities, medicinal uses, coordination behaviors [6- 8] and studying their properties computationally. However, it is very important to find effective and safe drugs that can target the virus and/or change how the immune system responds [9]. Pyrazole is an example of an N-heterocyclic molecule with two N-atoms and a five-member ring. It has a wide range of biological and pharmacological activities. The connections between pyrazole and other fivemembered N-heterocyclic molecules could lead to the creation of new molecules that move in different ways and have new biological properties. The biological activity of designed molecules 13 may be affected by how rigid or flexible a compound is. But molecules with more than one rotated bond can have very different shapes. Some of these shapes are good because they have low internal energies, while others are not. Therefore, when we made compounds, we thought about a few things to get them close to chloroquine both biologically and electronically. In fact, we focused on fused molecules that have more than one biologically active part. This was a continuation of our research interest in designing, making, and looking into the similarities between molecules of new fused molecules. Aromatic ring systems, especially fivemembered heterocyclic ring systems, can be added to make derivatives with the best size, but the aromaticity of these rings can have an unpredictable effect on the affinity of the binding site [ 10]. In addition, the stacking formation between the aromatic rings may make …