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Some novel appropriate amines linked to phthalimide moiety have been synthesized via microwave and reflux synthesizer. The phthalic anhydride was treated with various aliphatic amines (aminoethanol, aminopropanol, amino ethyl morphline, and some amino acids), the purity of the synthesized products were monitored by using TLC in an appropriate developing system. The structures of the new synthesized compounds were confirmed by using physical and spectral analysis. All the synthesized compounds were evaluated in vivo for analgesic activity by using standard experimental models. Compounds 2, 4 and 6 showed significant analgesic effect with hot plate and acetic acid inducer writhing tests in mice compared to the control group.