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JAC strains resistant to carbapenems constitutes an emerging threat worldwide. 1 The GES family of enzymes has been identified in several Gram-negative bacteria, such as P. aeruginosa, Klebsiella pneumoniae and Escherichia coli, being responsible for an extended resistance spectrum to several b-lactams. 2, 3 To date, according to the Lahey Clinic web site (http://www. lahey. org/Studies/), 24 variants of GES have been identified with some presenting carbapenemase activity, which is a matter of great concern. Few GES variants have been identified in Portugal, all of them found in Enterobacteriaceae. 3 In Portugal, carbapenemases associated with P. aeruginosa include VIM-2 (the most frequent) and also IMP-5. 4 Here, we report the first known worldwide description of the blaGES-6 gene in P. aeruginosa strains associated with a new genetic environment and also the first description of GES-producing P …