作者
F Fogacci, M Banach, DP Mikhailidis, E Bruckert, PP Toth, GF Watts, Z Reiner, GBJ Mancini, M Rizzo, O Mitchenko, DP Pella, Z Fras, AFG Sahebkar, M Vrablik, AFG Cicero
发表日期
2019/10/1
来源
European Heart Journal
卷号
40
期号
Supplement_1
页码范围
ehz748. 0078
出版商
Oxford University Press
简介
Background
Recently, concerns regarding the safety of red yeast rice (RYR) have been raised after the publication of some case reports claiming toxicity.
Purpose
Since the previous meta-analyses on the effects of RYR were mainly focused on its efficacy to improve the lipid profile and other cardiovascular parameters, we carried out a meta-analysis on safety data derived from the available randomized controlled clinical trials (RCTs).
Methods
Primary outcomes were musculoskeletal disorders (MuD). Secondary outcomes were non-musculoskeletal adverse events (Non-MuD) and serious adverse events (SAE). Subgroups analyses were carried out considering the intervention (RYR alone or in association with other nutraceutical compounds), monacolin K administered daily dose (≤3, <3–5 and >5 mg/day), follow-up (>12 or ≤12 weeks), with statin …
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F Fogacci, M Banach, DP Mikhailidis, E Bruckert… - European Heart Journal, 2019