作者
Jonathan Celli, Brian Gregor, Bradley Turner, Nezam H Afdhal, Rama Bansil, Shyamsunder Erramilli
发表日期
2005/5/9
期刊
Biomacromolecules
卷号
6
期号
3
页码范围
1329-1333
出版商
American Chemical Society
简介
Gastric mucin is a glycoprotein known to undergo a pH-dependent sol−gel transition that is crucial to the protective function of the gastric mucus layer in mammalian stomachs. We present microscope-based dynamic light scattering data on porcine gastric mucin at pH 6 (solution) and pH 2 (gel) with and without the presence of tracer particles. The data provide a measurement of the microscale viscosity and the shear elastic modulus as well as an estimate of the mesh size of the gel formed at pH 2. We observe that the microscale viscosity in the gel is about 100-fold lower than its macroscopic viscosity, suggesting that large pores open up in the gel reducing frictional effects. The data presented here help to characterize physiologically relevant viscoelastic properties of an important biological macromolecule and may also serve to shed light on diffusive motion of small particles in the complex heterogeneous …
引用总数
200520062007200820092010201120122013201420152016201720182019202020212022202320241344441010111913841415141010108
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J Celli, B Gregor, B Turner, NH Afdhal, R Bansil… - Biomacromolecules, 2005