作者
Yonathan Freund, Marine Cachanado, Adeline Aubry, Charlotte Orsini, Pierre-Alexis Raynal, Anne-Laure Féral-Pierssens, Sandrine Charpentier, Florence Dumas, Nacera Baarir, Jennifer Truchot, Thibaut Desmettre, Karim Tazarourte, Sebastien Beaune, Agathe Leleu, Mehdi Khellaf, Mathias Wargon, Ben Bloom, Alexandra Rousseau, Tabassome Simon, Bruno Riou, PROPER Investigator Group
发表日期
2018/2/13
期刊
Jama
卷号
319
期号
6
页码范围
559-566
出版商
American Medical Association
简介
Importance
The safety of the pulmonary embolism rule-out criteria (PERC), an 8-item block of clinical criteria aimed at ruling out pulmonary embolism (PE), has not been assessed in a randomized clinical trial.
Objective
To prospectively validate the safety of a PERC-based strategy to rule out PE.
Design, Setting, and Patients
A crossover cluster–randomized clinical noninferiority trial in 14 emergency departments in France. Patients with a low gestalt clinical probability of PE were included from August 2015 to September 2016, and followed up until December 2016.
Interventions
Each center was randomized for the sequence of intervention periods. In the PERC period, the diagnosis of PE was excluded with no further testing if all 8 items of the PERC rule were negative.
Main Outcomes and Measures
The primary end point was the occurrence of a thromboembolic event during the 3-month follow-up period that was not …
学术搜索中的文章
Y Freund, M Cachanado, A Aubry, C Orsini, PA Raynal… - Jama, 2018