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To investigate potential differences in the prediction of early‐ vs. late‐onset pre‐eclampsia and/or intrauterine growth restriction (PE/IUGR) by second‐trimester uterine artery Doppler examination, and measurement of maternal serum placental growth factor (PlGF) and soluble fms‐like tyrosine kinase 1 (sFlt1).

Uterine artery mean pulsatility index (PI) and maternal serum PlGF and sFlt1 levels were measured at 24 weeks of gestation in 76 healthy pregnant women and 38 cases of PE/IUGR, of which 19 were defined as early onset (< 32 weeks).

For a specificity of 95%, the sensitivities of uterine artery mean PI, PlGF and sFlt1 for early‐onset PE/IUGR were 47.4%, 84.4% and 36.8%, respectively. When combining uterine artery Doppler with PlGF, the sensitivity for identifying early‐onset PE/IUGR was 89.5% with a specificity of 95%. Conversely, the sensitivity for late‐onset PE/IUGR was …