作者
Marios Koutsakos, Patricia T Illing, Thi HO Nguyen, Nicole A Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A Eltahla, E Bridie Clemens, Sneha Sant, Brendon Y Chua, Chinn Yi Wong, E Kaitlynn Allen, Don Teng, Pradyot Dash, David F Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C Hurt, Ian Barr, Steve Rockman, David C Jackson, Tom C Kotsimbos, Allen C Cheng, Michael Richards, Glen P Westall, Thomas Loudovaris, Stuart I Mannering, Michael Elliott, Stuart G Tangye, Linda M Wakim, Jamie Rossjohn, Dhanasekaran Vijaykrishna, Fabio Luciani, Paul G Thomas, Stephanie Gras, Anthony W Purcell, Katherine Kedzierska
发表日期
2019/5
期刊
Nature immunology
卷号
20
期号
5
页码范围
613-625
出版商
Nature Publishing Group US
简介
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross-protection against IAV strains, however the responses of CD8+ T cells to IBV and ICV are understudied. We investigated the breadth of CD8+ T cell cross-recognition and provide evidence of CD8+ T cell cross-reactivity across IAV, IBV and ICV. We identified immunodominant CD8+ T cell epitopes from IBVs that were protective in mice and found memory CD8+ T cells directed against universal and influenza-virus-type-specific epitopes in the blood and lungs of healthy humans. Lung-derived CD8+ T cells displayed tissue-resident memory phenotypes. Notably, CD38+Ki67+CD8+ effector T cells directed against novel epitopes were readily detected in IAV- or IBV-infected pediatric and adult subjects. Our study introduces a new paradigm …
学术搜索中的文章
M Koutsakos, PT Illing, THO Nguyen, NA Mifsud… - Nature immunology, 2019