作者
Philip A Mudd, Anastasia A Minervina, Mikhail V Pogorelyy, Jackson S Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J Schmitz, Tingting Lei, Alem Haile, Allison M Kirk, Robert C Mettelman, Jeremy Chase Crawford, Thi HO Nguyen, Louise C Rowntree, Elisa Rosati, Katherine A Richards, Andrea J Sant, Michael K Klebert, Teresa Suessen, William D Middleton, Jeremie H Estepp, Stacey Schultz-Cherry, Maureen A McGargill, Aditya Gaur, James Hoffman, Motomi Mori, Li Tang, Elaine Tuomanen, Richard Webby, Randall T Hayden, Hana Hakim, Diego R Hijano, Kim J Allison, E Kaitlynn Allen, Resha Bajracharya, Walid Awad, Lee-Ann Van de Velde, Brandi L Clark, Taylor L Wilson, Aisha Souquette, Ashley Castellaw, Ronald H Dallas, Ashleigh Gowen, Thomas P Fabrizio, Chun-Yang Lin, David C Brice, Sean Cherry, Ericka Kirkpatrick Roubidoux, Valerie Cortez, Pamela Freiden, Nicholas Wohlgemuth, Kendall Whitt, Joshua Wolf, Sharlene A Teefey, Jane A O’Halloran, Rachel M Presti, Katherine Kedzierska, Jamie Rossjohn, Paul G Thomas, Ali H Ellebedy
发表日期
2022/2/17
期刊
Cell
卷号
185
期号
4
页码范围
603-613. e15
出版商
Elsevier
简介
SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (TFH) cell responses contribute to this outstanding immunogenicity. Using fine-needle aspiration of draining axillary lymph nodes from individuals who received the BNT162b2 mRNA vaccine, we evaluated the T cell receptor sequences and phenotype of lymph node TFH. Mining of the responding TFH T cell receptor repertoire revealed a strikingly immunodominant HLA-DPB1∗04-restricted response to S167–180 in individuals with this allele, which is among the most common HLA alleles in humans. Paired blood and lymph node specimens show that while circulating S-specific TFH cells peak one week after the second immunization, S-specific TFH persist at nearly constant frequencies for at least six months. Collectively, our results underscore the key …
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PA Mudd, AA Minervina, MV Pogorelyy, JS Turner… - Cell, 2022