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With the support of mobile cloud computing, wireless body area networks can be significantly enhanced for massive deployment of pervasive healthcare applications. However, several technical issues and challenges are associated with the integration of WBANs and MCC. In this article, we study a cloud-enabled WBAN architecture and its applications in pervasive healthcare systems. We highlight the methodologies for transmitting vital sign data to the cloud by using energy-efficient routing, cloud resource allocation, semantic interactions, and data security mechanisms.