作者
Amirhossein Sahebkar, Arrigo FG Cicero, Luis E Simental-Mendía, Bharat B Aggarwal, Subash C Gupta
发表日期
2016/5/1
来源
Pharmacological research
卷号
107
页码范围
234-242
出版商
Academic Press
简介
Background
Tumor necrosis factor-α (TNF-α) is a key inflammatory mediator and its reduction is a therapeutic target in several inflammatory diseases. Curcumin, a bioactive polyphenol from turmeric, has been shown in several preclinical studies to block TNF-α effectively. However, clinical evidence has not been fully conclusive.
Objective
The aim of the present meta-analysis was to evaluate the efficacy of curcumin supplementation on circulating levels of TNF-α in randomized controlled trials (RCTs).
Methods
The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to September 21, 2015, to identify RCTs investigating the impact of curcumin on circulating TNF-α concentration. Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics. Meta-regression and leave …
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A Sahebkar, AFG Cicero, LE Simental-Mendía… - Pharmacological research, 2016