作者
Agostino Virdis, Stefano Masi, Edoardo Casiglia, Valerie Tikhonoff, Arrigo FG Cicero, Andrea Ungar, Giulia Rivasi, Massimo Salvetti, Carlo M Barbagallo, Michele Bombelli, Raffaella Dell’Oro, Berardino Bruno, Luciano Lippa, Lanfranco D’Elia, Paolo Verdecchia, Francesca Mallamaci, Massimo Cirillo, Marcello Rattazzi, Pietro Cirillo, Loreto Gesualdo, Alberto Mazza, Cristina Giannattasio, Alessandro Maloberti, Massimo Volpe, Giuliano Tocci, Georgios Georgiopoulos, Guido Iaccarino, Pietro Nazzaro, Gianfranco Parati, Paolo Palatini, Ferruccio Galletti, Claudio Ferri, Giovambattista Desideri, Francesca Viazzi, Roberto Pontremoli, Maria Lorenza Muiesan, Guido Grassi, Claudio Borghi, from the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension
发表日期
2020/2
期刊
Hypertension
卷号
75
期号
2
页码范围
302-308
出版商
Lippincott Williams & Wilkins
简介
Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed the threshold of SUA that increases the risk of total mortality and cardiovascular mortality (CVM). The URRAH study (Uric Acid Right for Heart Health) is a multicentre retrospective, observational study, which collected data from several large population-based longitudinal studies in Italy and subjects recruited in the hypertension clinics of the Italian Society of Hypertension. Total mortality was defined as mortality for any cause, CVM as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure. A total of 22 714 subjects were included in the analysis. Multivariate Cox regression analyses identified an independent association between SUA and total mortality (hazard ratio, 1.53 [95% CI, 1.21–1.93]) or CVM (hazard ratio, 2.08 …
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A Virdis, S Masi, E Casiglia, V Tikhonoff, AFG Cicero… - Hypertension, 2020