作者
Francesco Missale, Filippo Marchi, Andrea Iandelli, Narayana Subramaniam, Yogesh Dokhe, Claudio Sampieri, Davide Mattavelli, Lorenzo Bresciani, Andrea Luigi Camillo Carobbio, Alberto Grammatica, Krishnakumar Thankappan, Subramania Iyer, Walter Fontanella, Lorenzo Giannini, Giorgio Peretti, Giampiero Parrinello, Deepak Balasubramanian, Cesare Piazza
发表日期
2022/12/1
期刊
Oral Oncology
卷号
135
页码范围
106210
出版商
Pergamon
简介
Objectives
Oral tongue carcinomas represent more than half of the tumors arising in the oral cavity, a site with a high cancer specific mortality and impact on quality of life. Current guidelines are lacking for a standardized surgical approach of these tumors. The aim of this study is to compare two currently adopted surgical strategies, compartmental surgery (CTS) and wide local excision (WLE), with loco-regional control as the main oncological endpoint.
Materials and methods
An observational retrospective multicentric study was carried out enrolling a cohort of patients affected by oral tongue or floor of the mouth squamous cell carcinoma and surgically treated in 4 international tertiary referral centers. Survival analysis was performed by propensity-score matching approach and multivariable Cox regression analysis.
Results
A cohort of 933 patients was enrolled. CTS was applied in 113 patients (12.1%) and WLE in 820 …
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F Missale, F Marchi, A Iandelli, N Subramaniam… - Oral Oncology, 2022