作者
Nicola F Müller, Cassia Wagner, Chris D Frazar, Pavitra Roychoudhury, Jover Lee, Louise H Moncla, Benjamin Pelle, Matthew Richardson, Erica Ryke, Hong Xie, Lasata Shrestha, Amin Addetia, Victoria M Rachleff, Nicole AP Lieberman, Meei-Li Huang, Romesh Gautom, Geoff Melly, Brian Hiatt, Philip Dykema, Amanda Adler, Elisabeth Brandstetter, Peter D Han, Kairsten Fay, Misja Ilcisin, Kirsten Lacombe, Thomas R Sibley, Melissa Truong, Caitlin R Wolf, Michael Boeckh, Janet A Englund, Michael Famulare, Barry R Lutz, Mark J Rieder, Matthew Thompson, Jeffrey S Duchin, Lea M Starita, Helen Y Chu, Jay Shendure, Keith R Jerome, Scott Lindquist, Alexander L Greninger, Deborah A Nickerson, Trevor Bedford
发表日期
2021/5/26
期刊
Science Translational Medicine
卷号
13
期号
595
页码范围
eabf0202
出版商
American Association for the Advancement of Science
简介
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gravely affected societies around the world. Outbreaks in different parts of the globe have been shaped by repeated introductions of new viral lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2 viral genomes from Washington State (USA) to characterize how the spread of SARS-CoV-2 in Washington State in early 2020 was shaped by differences in timing of mitigation strategies across counties and by repeated introductions of viral lineages into the state. In addition, we show that the increase in frequency of a potentially more transmissible viral variant (614G) over time can potentially be explained by regional mobility differences and multiple introductions of 614G but not the other variant (614D) into the state. At an individual level, we observed evidence of higher viral loads …
学术搜索中的文章
NF Müller, C Wagner, CD Frazar, P Roychoudhury… - Science Translational Medicine, 2021