作者
John E Bowen, Amin Addetia, Ha V Dang, Cameron Stewart, Jack T Brown, William K Sharkey, Kaitlin R Sprouse, Alexandra C Walls, Ignacio G Mazzitelli, Jennifer K Logue, Nicholas M Franko, Nadine Czudnochowski, Abigail E Powell, Exequiel Dellota Jr, Kumail Ahmed, Asefa Shariq Ansari, Elisabetta Cameroni, Andrea Gori, Alessandra Bandera, Christine M Posavad, Jennifer M Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Najeeha Talat Iqbal, Davide Corti, Jorge Geffner, Gyorgy Snell, Renata Grifantini, Helen Y Chu, David Veesler
发表日期
2022/8/19
期刊
Science
卷号
377
期号
6608
页码范围
890-894
出版商
American Association for the Advancement of Science
简介
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary …
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JE Bowen, A Addetia, HV Dang, C Stewart, JT Brown… - Science, 2022