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Background

Over the counter (OTC) artificial tears historically have been the first line of treatment for dry eye syndrome and dry eye‐related conditions like contact lens discomfort, yet currently we know little regarding the overall efficacy of individual, commercially available artificial tears. This review provides a much needed meta‐analytical look at all randomized and quasi‐randomized clinical trials that have analyzed head‐to‐head comparisons of OTC artificial tears.

Objectives

To evaluate the effectiveness and toxicity of OTC artificial tear applications in the treatment of dry eye syndrome compared with another class of OTC artificial tears, no treatment, or placebo.