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We present longitudinal functional activity imaging of liver functional zones in the presence of metabolic inhibitor drug with dynamic optical coherence tomography (DOCT). We studied a normal liver and a liver injected with metformin. In the normal liver, we found a correlation between the vascular structures observed in the DOCT and OCT projections. Over time, these vascular structures gradually decreased in the DOCT, while similar structures appeared in the OCT at a later time point. In the metformin-injected liver, we observed hexagonal liver lobule structures in the OCT. At late time point, several vessel-like structures with increased scattering appeared in the OCT, which were not initially present in the DOCT.