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Information technology has rapidly penetrated into the healthcare sector and it has been proved that it can lead to better decision support, organizational support and even influence the quality of the services offered to patients. The evaluation of any HIS is, therefore, a very critical issue. After an extended and systematic review of the existing literature, user satisfaction was chosen as the measurement of IS success. The proposed research model of IS success is based on widely validated user satisfaction models. System quality, information quality, service quality and user bac ground were selected to measure user satisfaction. A structured questionnaire has been used to collect data from four Gree state hospitals, in order to empirically test the validity of the proposed model. Structural Equation Modeling is the main statistical technique used to test the fit of the structural model. The main conclusion is that user bac ground, information quality and service quality directly and positively affect user satisfaction confirming three out of four initial hypotheses (H1, H3, and H4). System quality has been found to influence user satisfaction only indirectly, through information quality, but not directly, as it was initially stated.